In Vitro 3D Cell Culture: An Overview
Flocel’s family of Dynamic In Vitro Blood-Brain Barrier (DIV- BBB) products represents the first flow-based, 3D in vitro model of the blood-brain barrier (BBB). Our innovative technology utilizes human endothelial cells and the formation of tight junctions to reflect in a physiologically accurate manner the characteristics of the BBB.
The DIV-BBB 3.0 replicates important endothelial cell-astrocyte interactions and can sustain up to four cell culture modules. It enables more accurate pharmacokinetic and toxicological studies and substantially reduces both the experimental time and the cost of drug development. The cell culture modules can be used to model not only the BBB, but also the blood-bone marrow, placental, and blood-CSF barriers. The modules can also be utilized for pericyte, epithelial, and tumor cell growth analysis, and much more!
We developed a method to make the hollow fiber wall transparent to allow for imaging of lumenal endothelial cells
PRODUCTS REVIEW
The features of the DIV-BBB system provide the most physiologically relevant in vitro model for studies of viral interactions with the blood-brain barrier
Nicola Fletcher University College Dublin
Flocel Inc is an outstanding company that offers a well-developed dynamic in vitro 3D BBB model platform that enables analysis of BBB physiology and function and is ideal for conducting pharmacokinetic/ pharmacodynamic experiments for neurotherapeutic drugs. I have been using their BBB model for over 10 years to study drug delivery of nanotherapeutics to the CNS and the scientific and technical support provided by Flocel Inc is unparalleled.
Supriya Mahajan Univ. of Buffalo
Fantastic, compact and versatile perfusion bioreactor with integrated TEER technology. You can easily tailor to adapt to your research needs. Great technology and excellent professional advice. Very recommendable
Dr. Diban-Ibrahim Gomez Universidad de Cantabria
Fantastic, compact and versatile perfusion bioreactor with integrated TEER technology. You can easily tailor to adapt to your research needs. Great technology and excellent professional advice. Very recommendable
Dr. Diban-Ibrahim Gomez Universidad de Cantabria
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