In contrast to other available models of the blood-brain barrier, the DIV-BBB respects the anatomical aspects of the in situ endothelial cell-astrocyte interactions and allows the formation of tight junctions that can be easily visualized at the electron microscope or determined experimentally with the use of tracers.
Features
Controlled ratio of luminal to ablumenal volume
Small size, only 2.75 inches long
Electrodes built into the cartridge
Low cost
Benefits
Matches volume ratio found in vivo.
Reduces the number of cells required.
TEER measurements are easily made.
One-time use, no rebuilding the cartridge.
Flocel Cartridge ..................
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Specifications
Hydrophobic capillaries:
Accurel® PP Q3/2 (optionally pre-coated with ProNectin® F or Poly-D-Lysine)
Trans-capillary pore size:
nominal 0.2 μm
Number of hollow fibers:
19
Total lumen internal volume:
0.0123 in3 = 0.202 cm3
Total lumen internal surface area:
2.09 in2 = 13.5 cm2
Volume of extralumenial space (ECS):
0.070 in3 = 1.15 cm3
Total hollow fiber area in ECS:
3.50 in2 = 22.6 cm2
Cartridges are delivered in a sealed bag, sterile and wetted with distilled water.
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