The Dynamic in Vitro Blood Brain Barrier (DIV-BBB) is an easily configurable and monitoring system which measures the integrity of the BBB. This system uses a Dynamic model, which continuously pumps nutrients through the models lumenal space. This adds shear stress on the endothelial cells in the model, and allows these cells to have a higher degree of differentiation and stronger tight junctions between each endothelial cell. Thus the DIV-BBB exemplifies an in vitro model that more accurately describes the in vivo conditions of the BBB.

The Flocel DIV-BBB package contains:

•DIV-BBB Cartridge
This cartridges small and versatile design, with it’s built in electrodes and hollow fibers makes the DIV-BBB Cartridge a significant and cost effective tool.

•TEER Measurement System
The Trans Epithelial Electrical Resistance (TEER) measurement provides a quick and easy evaluation of the integrity of the Blood-Brain Barrier model.

•Pulsatile Quad Pump
The Quad Pump is an integral component of the Flocel systems that mimics the pulsating action of a real heart, and helps induce the Dynamic conditions of this system.

•Gas-permeable Tubing
The Tubing is an essential component of the Dynamic BBB model, as it is the throughway for the essential nutrients to be pumped in and out of the DIV-BBB cartridge.

Download the Flocel System Brochure here.