Every year millions of dollars are spent by pharmaceutical companies to develop and test drugs using in vitro models of the Blood-Brain Barrier (BBB), many of which end up not working in vivo. CleveMed has licensed technology from The Cleveland Clinic Foundation and formed Flocel Inc., to manufacture and market a practical in vitro model that more accurately reflects the BBB characteristics.

Matches volume ratio found in vivo

Can use real human cells

Reduces the number of cells required

TEER measurements are easily made

More accurate pharmacokinetic and toxicological studies

One-time use, no rebuilding the cartridge

Cost effective

For decades, scientists have been trying to develop methods of testing the effects of drugs on the brain that is both safe and cost-effective. Find out more...

Flocel has developed a different model of the blood-brain barrier, DIV-BBB respects the anatomical aspects of the in situ endothelial cell-astrocyte interactions Find out more...